The Coding Causes of Death in HIV (CoDe) Project Initial Results and Evaluation of Methodology
Identifieur interne : 006663 ( Main/Exploration ); précédent : 006662; suivant : 006664The Coding Causes of Death in HIV (CoDe) Project Initial Results and Evaluation of Methodology
Auteurs : Justyna D. Kowalska [Danemark] ; Nina Friis-M Ller [Danemark] ; Ole Kirk [Danemark] ; Wendy Bannister [Royaume-Uni] ; Amanda Mocroft [Royaume-Uni] ; Caroline Sabin [Danemark] ; Peter Reiss [Pays-Bas] ; John Gill [Canada] ; Charlotte Lewden [France] ; Andrew Phillips [Royaume-Uni] ; Antonella D'Arminio Monforte [Italie] ; Matthew Law [Australie] ; Jonathan Sterne [Royaume-Uni] ; Stephane De Wit [Belgique] ; Jens D. Lundgren [Danemark]Source :
- Epidemiology : (Cambridge, Mass.) [ 1044-3983 ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Codage, Mort, Mortalité, Santé publique.
English descriptors
- KwdEn :
Abstract
Background: The Coding Causes of Death in HIV (CoDe) Project aims to deliver a standardized method for coding the underlying cause of death in HIV-positive persons, suitable for clinical trials and epidemiologic studies. Methods: The project incorporates detailed data collection, a classification system, and a centralized adjudication process performed by 2 independent reviewers. The methodology was tested in the Data Collection on Adverse events of Anti-HIV Drugs Study, and independent reviews of causes of death were compared. Logistic regression models identified factors associated with initial agreement by reviewers on underlying cause of death. Results: A total of 491 reported fatal cases were adjudicated; in only 5% of cases the cause of death remained undetermined after adjudication. Reviewers initially agreed on the underlying cause for 339 (69%) deaths. As compared with deaths due to AIDS-related causes, the odds of agreement were more than 80% lower when deaths were ultimately deemed to be due to non-AIDS-related causes (odds ratio = 0.17 [95% confidence interval = 0.08-0.37]) or undetermined causes (0.11 [0.04-0.36]). The odds of initial agreement were also lower for deaths occurring in subjects with hypertension (0.43 [0.22-0.85]) and depression (0.43 [0.23-0.80]). Conclusions: The extent and format of data collected in the CoDe Project appear to be sufficient for an informed review, and the proposed coding scheme is adequate for obtaining an underlying cause of death.
Affiliations:
- Australie, Belgique, Canada, Danemark, France, Italie, Pays-Bas, Royaume-Uni
- Angleterre, Aquitaine, Grand Londres, Hollande-Septentrionale, Hovedstaden, Lombardie, Nouvelle-Aquitaine, Nouvelle-Galles du Sud, Région de Bruxelles-Capitale
- Amsterdam, Bordeaux, Bruxelles, Copenhague, Londres, Milan, Sydney
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Kowalska</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Copenhagen HIV Programme, University of Copenhagen, Faculty of Health Sciences</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Friis M Ller, Nina" sort="Friis M Ller, Nina" uniqKey="Friis M Ller N" first="Nina" last="Friis-M Ller">Nina Friis-M Ller</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Copenhagen HIV Programme, University of Copenhagen, Faculty of Health Sciences</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Copenhagen HIV Programme, University of Copenhagen, Faculty of Health Sciences</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Infectious Diseases, Rigshospitalet</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>3 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Bannister, Wendy" sort="Bannister, Wendy" uniqKey="Bannister W" first="Wendy" last="Bannister">Wendy Bannister</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>University College London Medical School, Royal Free Campus</s1><s2>London</s2><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mocroft, Amanda" sort="Mocroft, Amanda" uniqKey="Mocroft A" first="Amanda" last="Mocroft">Amanda Mocroft</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>University College London Medical School, Royal Free Campus</s1><s2>London</s2><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sabin, Caroline" sort="Sabin, Caroline" uniqKey="Sabin C" first="Caroline" last="Sabin">Caroline Sabin</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Copenhagen HIV Programme, University of Copenhagen, Faculty of Health Sciences</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>HIV Monitoring Foundation, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Gill, John" sort="Gill, John" uniqKey="Gill J" first="John" last="Gill">John Gill</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>S Alberta HIV Clinic, Sheldon M Chumir Health Centre</s1><s2>Calgary</s2><s3>CAN</s3><sZ>8 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Calgary</wicri:noRegion></affiliation></author><author><name sortKey="Lewden, Charlotte" sort="Lewden, Charlotte" uniqKey="Lewden C" first="Charlotte" last="Lewden">Charlotte Lewden</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Bordeaux School of Public Health, Institut de Santé Publique, d'Epidémiologie et de Développement</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Phillips, Andrew" sort="Phillips, Andrew" uniqKey="Phillips A" first="Andrew" last="Phillips">Andrew Phillips</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>University College London Medical School, Royal Free Campus</s1><s2>London</s2><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="D Arminio Monforte, Antonella" sort="D Arminio Monforte, Antonella" uniqKey="D Arminio Monforte A" first="Antonella" last="D'Arminio Monforte">Antonella D'Arminio Monforte</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Hospital San Paolo, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>National Centre in HIV Epidemiology and Clinical Research</s1><s2>Sydney</s2><s3>AUS</s3><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Sterne, Jonathan" sort="Sterne, Jonathan" uniqKey="Sterne J" first="Jonathan" last="Sterne">Jonathan Sterne</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Social Medicine, University of Bristol</s1><s2>Bristol</s2><s3>GBR</s3><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="De Wit, Stephane" sort="De Wit, Stephane" uniqKey="De Wit S" first="Stephane" last="De Wit">Stephane De Wit</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Infectious Diseases, Centre Hospitalier Universitaire Saint-Pierre Hospital</s1><s2>Brussels</s2><s3>BEL</s3><sZ>14 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Copenhagen HIV Programme, University of Copenhagen, Faculty of Health Sciences</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Infectious Diseases, Rigshospitalet</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>3 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Epidemiology : (Cambridge, Mass.)</title><title level="j" type="abbreviated">Epidemiology : (Camb. Mass.)</title><idno type="ISSN">1044-3983</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Epidemiology : (Cambridge, Mass.)</title><title level="j" type="abbreviated">Epidemiology : (Camb. Mass.)</title><idno type="ISSN">1044-3983</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term><term>Causality</term><term>Cause</term><term>Code</term><term>Coding</term><term>Death</term><term>Epidemiology</term><term>Evaluation</term><term>Human immunodeficiency virus</term><term>Methodology</term><term>Mortality</term><term>Public health</term><term>Result</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Codage</term><term>Mort</term><term>Cause</term><term>Causalité</term><term>Mortalité</term><term>SIDA</term><term>Virus immunodéficience humaine</term><term>Code</term><term>Résultat</term><term>Evaluation</term><term>Méthodologie</term><term>Santé publique</term><term>Epidémiologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Codage</term><term>Mort</term><term>Mortalité</term><term>Santé publique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: The Coding Causes of Death in HIV (CoDe) Project aims to deliver a standardized method for coding the underlying cause of death in HIV-positive persons, suitable for clinical trials and epidemiologic studies. Methods: The project incorporates detailed data collection, a classification system, and a centralized adjudication process performed by 2 independent reviewers. The methodology was tested in the Data Collection on Adverse events of Anti-HIV Drugs Study, and independent reviews of causes of death were compared. Logistic regression models identified factors associated with initial agreement by reviewers on underlying cause of death. Results: A total of 491 reported fatal cases were adjudicated; in only 5% of cases the cause of death remained undetermined after adjudication. Reviewers initially agreed on the underlying cause for 339 (69%) deaths. As compared with deaths due to AIDS-related causes, the odds of agreement were more than 80% lower when deaths were ultimately deemed to be due to non-AIDS-related causes (odds ratio = 0.17 [95% confidence interval = 0.08-0.37]) or undetermined causes (0.11 [0.04-0.36]). The odds of initial agreement were also lower for deaths occurring in subjects with hypertension (0.43 [0.22-0.85]) and depression (0.43 [0.23-0.80]). Conclusions: The extent and format of data collected in the CoDe Project appear to be sufficient for an informed review, and the proposed coding scheme is adequate for obtaining an underlying cause of death.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Canada</li><li>Danemark</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Hovedstaden</li><li>Lombardie</li><li>Nouvelle-Aquitaine</li><li>Nouvelle-Galles du Sud</li><li>Région de Bruxelles-Capitale</li></region><settlement><li>Amsterdam</li><li>Bordeaux</li><li>Bruxelles</li><li>Copenhague</li><li>Londres</li><li>Milan</li><li>Sydney</li></settlement></list><tree><country name="Danemark"><region name="Hovedstaden"><name sortKey="Kowalska, Justyna D" sort="Kowalska, Justyna D" uniqKey="Kowalska J" first="Justyna D." last="Kowalska">Justyna D. Kowalska</name></region><name sortKey="Friis M Ller, Nina" sort="Friis M Ller, Nina" uniqKey="Friis M Ller N" first="Nina" last="Friis-M Ller">Nina Friis-M Ller</name><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name><name sortKey="Sabin, Caroline" sort="Sabin, Caroline" uniqKey="Sabin C" first="Caroline" last="Sabin">Caroline Sabin</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Bannister, Wendy" sort="Bannister, Wendy" uniqKey="Bannister W" first="Wendy" last="Bannister">Wendy Bannister</name></region><name sortKey="Mocroft, Amanda" sort="Mocroft, Amanda" uniqKey="Mocroft A" first="Amanda" last="Mocroft">Amanda Mocroft</name><name sortKey="Phillips, Andrew" sort="Phillips, Andrew" uniqKey="Phillips A" first="Andrew" last="Phillips">Andrew Phillips</name><name sortKey="Sterne, Jonathan" sort="Sterne, Jonathan" uniqKey="Sterne J" first="Jonathan" last="Sterne">Jonathan Sterne</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name></region></country><country name="Canada"><noRegion><name sortKey="Gill, John" sort="Gill, John" uniqKey="Gill J" first="John" last="Gill">John Gill</name></noRegion></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Lewden, Charlotte" sort="Lewden, Charlotte" uniqKey="Lewden C" first="Charlotte" last="Lewden">Charlotte Lewden</name></region></country><country name="Italie"><region name="Lombardie"><name sortKey="D Arminio Monforte, Antonella" sort="D Arminio Monforte, Antonella" uniqKey="D Arminio Monforte A" first="Antonella" last="D'Arminio Monforte">Antonella D'Arminio Monforte</name></region></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name></region></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="De Wit, Stephane" sort="De Wit, Stephane" uniqKey="De Wit S" first="Stephane" last="De Wit">Stephane De Wit</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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